A placebo-controlled research study, conducted at the Aarhus University Hospital in Denmark, evaluated the effects of resveratrol on bone in men with metabolic syndrome. Resveratrol is found naturally in grapes and red wine. The study population comprised of 74 middle-aged obese men with a mean body mass index of 33.7.
The men were randomly placed into three groups and orally given 1000 mg resveratrol, 150 mg resveratrol or placebo daily for 16 weeks. The change in bone alkaline phosphatase (BAP) was monitored and found to increase significantly in the resveratrol groups. Bone mineral density also increased dose dependently compared to placebo. The data suggests that high-dose resveratrol supplementation positively affects bone, primarily by stimulating formation or mineralization.
Source: The Journal of Clinical Endocrinology & Metabolism DOI:http://dx.doi.org/10.1210/jc.2014-2799